Document Type
Article
Publication Date
2025
Publication Title
BioChem
Abstract
Traditional materials synthesis often involves energy-intensive processes with significant waste generation and limited control over material properties. This review examines synthetic biology as a sustainable alternative for designing advanced materials with enhanced precision and versatility. It explores microbial biomineralization, detailing how microorganisms influence the formation of mineral deposits and participate in key biogeochemical cycles. It highlights recent research advancements in using a wide variety of microorganisms for the synthesis of inorganic materials such as metal and metal oxide nanoparticles, quantum dots, magnetic nanoparticles, and thin films. The review also discusses the production and properties of various biopolymers. Important factors that can influence the size, morphology, and uniformity of these biomaterials are covered in detail. Emphasis is placed on advancements utilizing synthetic biology tools, such as protein engineering and genome editing, and recent research for creating smart and responsive materials. Considering the present limitations of synthetic biology, challenges related to scale-up, yield, and uniformity are discussed, and suggestions for future research are detailed.
Recommended Citation
Ramachandran, Roshini; Macabenta, Frank; Bettencourt, Grace; and Feng, Shulammite, "From Microbes to Molecules: Synthetic Biology Approaches for Advanced Materials Design" (2025). Biology and Chemistry Faculty Publications and Presentations. 51.
https://digitalcommons.csumb.edu/biochem_fac/51
Comments
Published in BioChem by MDPI. Available via doi: 10.3390/biochem5020012.
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/ licenses/by/4.0/).